Sentence examples for use of a mutation from inspiring English sources

During each iteration, a second new population is formed from an existing population through the use of a mutation operator.

To further validate the sensitivity of this parameter, we made use of a mutation (β2-R207C β2-R207C in the GABA-binding site), known to induce a reduction in GABA sensitivity (see alocatedner and Czajkowskin 2001; Wagner ethel., 2004).

We have shown that use of a mutation cassette in which synonymous codons restore the coding sequence of the gene after integration into the genome has the double benefit of maintaining function and limiting the region within which homologous recombination can take place, thereby increasing the proportion of crossovers that incorporate the desired change into the genome.

Specifically, the use of a conserved mutation helped us demonstrate that the methyl-binding surface in the Tudor domain of TDRD3 is involved in this process.

The small discrepancy may be due to their use of a lower mutation rate (10-5 vs. 2.5 × 10-5 in our study) and possible biased sampling of sites with higher underlying mutation rates in their study [ 5].

However, use of a fixed mutation rate can produce sub-optimal solutions.

Thus, we explored the use of a false mutation proportion subtraction methodology that we developed in-house.

Use of a genomic mutation or amplification of a gene related to the mechanism of action of the drug as a predictive biomarker is more scientifically satisfying.

To gain further insights into the mechanism of release modulation following Munc18-1 phosphorylation, we made use of a phosphomimetic mutation of Munc18-1, in which the S306 and S313 sites were changed to aspartate residues (called M18SD mutant).

Both the ACOG and the ACMG recommend use of a 23-mutation panel, which tests for all CF-associated mutations with an allele frequency of at least 0.1% in the general US population.

It is shown that the use of a time/space varying mutation operator depending on the values achieved for each objective function increases the performance of the algorithm.