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However, the use of a hypothetical case allowed us to assess physicians' decision-making regarding referral under similarly realistic conditions, and the inclusion of serum creatinine in the scenario would not have impacted within-individual-physician differences in their referrals when using serum creatinine versus eGFR.
The use of a hypothetical event in the patients treated with DMARDs also prevented us presenting adjusted incidence rate ratios because it would be inappropriate to adjust results according to the characteristics of an arbitrarily selected patient, therefore the differences between the patients in the anti-TNF treated and comparison cohorts cannot be completely accounted for.
The impact of using different antimalarials in the HMM programme and at health facilities was also explored, including use of a hypothetical 'ideal' antimalarial, which was assumed to be inexpensive (cost equivalent to chloroquine), and 100% effective, providing post-treatment prophylaxis for 4 weeks.
All FD patients were queried about the use of a hypothetical medication that could permanently cure their FD symptoms, defined a priori as symptom resolution without the need for further medications for FD symptoms.
For example, the use of a hypothetical scenario may have resulted in critical care physicians stating that they use resuscitation parameters similar to those described by Rivers and coworkers more often than in actual practice.
Furthermore, the use of a hypothetical event in the comparison cohort to generate incident rate ratios will lead to an underestimate of the true rate ratios between the cohorts.
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The effects of DG on load and network parameters is investigated in this paper through the use of a developed hypothetical commercial reticulation network and load demand profiles.
The methodology is demonstrated using two variants of a hypothetical naval ship.
Furthermore, by using case study of a hypothetical office building, this paper showcases how the IMEUM output can be fully converted into a localized weather data file for cooling load simulation.
18 We calculated the affordability of each oral hypoglycaemic agent separately using the cost of a hypothetical monthly treatment (30 DDDs).
From the point of view of budget impact, the total burden of 100% (single) use of rosuvastatin in a hypothetical cohort of 100 patients for one year was €1.14 million versus €1.25 million for atorvastatin, €1.30 million for simvastatin, and €1.34 million for pravastatin.
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