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Qualification is necessary for use of a biomarker as a surrogate endpoint.
The use of a biomarker to measure the treatment effects of an intervention is complex.
Nonetheless, histopathology validation is important and can substantiate the use of a biomarker in phase I/II trials.
However, this methodology still makes use of a biomarker whose correlation to proarrhythmic risk is not absolute.
Previous studies have demonstrated that 4 to 5 tumor punches on an array was sufficient to validate the use of a biomarker on a TMA [ 23].
The use of a biomarker of arsenic exposure may help to improve the assessment of low-dose health effects, including cancer incidence (Karagas et al. 2002).
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Tyrosine kinase inhibitors comprise a group of anticancer drugs where effectiveness may be improved through use of a biomarker-guided dose individualization approach.
The use of TBHg, a biomarker reflective of recent MeHg exposure [ 15], is consistent with the one-month seafood intake data available in NHANES.
Recently, Siman and colleagues [ 55] studied combinations of neurodegeneration biomarkers for predicting vasospasm, infarction and outcome rather than the use of a single biomarker.
The intended use of a cancer biomarker would hence be early stage diagnosis and/or prognosis.
It is unlikely that the multifaceted nature of severe sepsis or ARDS would be only monitored with the use of a single biomarker.
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