However, these curcuminoids suffer from low aqueous solubility, poor bioavailability, and low stability and therefore, have limited practical use, necessitating the modification of their properties in order to develop a versatile, useful and effective therapeutic product [2].
While mtDNA may offer several advantages for the study of parasitic plants, its use necessitates careful consideration of the possibility of horizontal gene transfer (HGT) [ 19- 26].
It has been noted previously by this group [ 57, 58] that the main drawback with MFEs is the difficulty involved in regenerating the active mercury surface after use, necessitating the inclusion of cleaning and mercury film renewal procedures.
Their effective and reliable clinical uses necessitate insightful analyses of the nonlinear characteristics, which has so far received little attention in literature.
Finally, although interindividual variability and noncriterial recollection may both contribute to the effects of aging on measures of recollection, it is additionally possible that the subjective and objective tests of recollection that are typically used necessitate somewhat different processing demands.
By the end of filming, more than a million feet of negative had been used, necessitating significant editing.
For the 3-year follow-up, a scannable booklet was used, necessitating some changes to the response options and layout (relative to earlier phases).
The large set of potential monitoring use cases necessitates analysis tools which provide a vast range of functionality.
Many of the component measurements are subjective, imprecise and insensitive to change and their use often necessitates lengthy and costly clinical trials using large cohorts of patients.
The trend towards greater alternative medicine use worldwide necessitates not only stringent labeling regulations and better consumer risk communication, but also improved surveillance of adverse events.
