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The particular simulation technique that we use is explained in Section 6.1.

Modules are described below, and their use is explained in Table 1.

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The cloning strategy used, is explained in figure 5.

Then, the first 500 markers (why 500 markers were used is explained in the Discussion section) with the lowest P-values were selected for the multiple-SNP analysis.

The four groups are collectively referred to as the total population T, births are represented as the special state B, and deaths as the special state D. A diagram for the first age group is shown in Figure 1 (notation used is explained in the section Describing states, populations and transitions between states).

Then the three tools that are used are explained in detail.

Cluster centroids are initialized; the different initialization schemes used are explained in the next section.

The statistical comparisons were performed as described in materials and methods, and the abbreviations used are explained in Table 3. ** p ≤ 0.01.

The derivation and normalization of the models using this formalism is explained in detail in the supplementary appendix.

Also the preparation steps before using MOLA and the possibility of using VirtualBox for booting is explained in detail.

The distribution of τi used in the simulation is explained in the next subsection.

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