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"The results certainly don't offer any support to Amgen's defense of Aranesp's use in this indication, but neither do they definitely establish that the use of the drug is detrimental in all cancer patients," Geoff Porges at Sanford C. Bernstein & Company wrote in a note to clients.
There is insufficient information available to define the optimal dose and scheduling for their use in this indication (recommendation).
In our preliminary clinical experience, as well as in that of others [ 12], loxapine characteristics and tolerance seem appropriate for use in this indication.
That change may be due to a combination of substantial increase in evidence, education and the introduction and marketing of drugs licensed for use in this indication.
Tocilizumab, a chimeric monoclonal antibody blocking interleukin-6-mediated signal transduction, was recently studied in patients not responding to TNF inhibitors [ 23], and the European Commission has recently approved its use in this indication.
The positive results of two randomized clinical trials in antineutrophil cytoplasmic antibody (ANCA -associated vANCA -associated] will increase their use in this indication, sometimes as a first line therapy.
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Methotrexate is widely used in this indication in Europe.
HFNC is increasingly used in this indication even if there are no randomized studies evaluating its efficacy and safety in this population.
Valproic acid, which has been used as an antiepileptic drug for many years and still is used in this indication, has been shown to inhibit preferably class I HDACs in the high micromolar to millimolar range.
Positron Emission Tomography/Computed Tomography (PET/CT) with F-Fluorodeoxyglucose ( F-FDG) is also often used in this indication, given that F-FDG has affinity for both primary and secondary breast tumors, depending on size and aggressiveness [ 2- 4].
Both the products under discussion are approved for use in the indication under consideration.
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