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Although we focus on SpCas9, particularly its use in therapeutic applications and the development of next-generation transformational drugs in T cells, the general outline described here applies to the larger ensemble of CRISPR/Cas9 tools.
Accumulating reports strongly indicate the potential diagnostic applications of miRNA in human cancers, also suggesting their possible use in therapeutic applications [19], [32], [33].
Our studies indicate that ATRA is able to potentiate the ability of TGF-β treated human CD4 T cells to impersonate human T regulatory cells but ATRA as a single agent is unable to promote the generation of Tregs that are attractive for use in therapeutic applications.
Reliable rhμPlg production (for use in therapeutic applications) is feasible using genetically modified P. pastoris as a host strain.
Therefore, the possibility of producing rhμPlg for use in therapeutic applications could be fulfilled by P. pastoris.
We further demonstrate effects of (i) disease status, (ii) airway surface leukocyte populations and (iii) mouse strain on macrophage AuNP clearance, which are all relevant for their use in therapeutic applications.
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In this study, poly-l-lactide (PL) scaffold surfaces were functionalized using layers of cerium oxide nanoparticles (CNPs), which have recently attracted attention for use in therapeutic application due to their catalytic ability of Ce4+ and Ce3+ sites.
Nanomaterials that are used in therapeutic applications need a high degree of uniformity and functionality which can be difficult to attain.
Furthermore, being a melatonergic drug, agomelatine has the potential of being used in therapeutic applications like melatonin as an antioxidant, anti-inflammatory and antiapoptotic drug.
We conducted simulations and measurements for 177Lu, which is used in therapeutic applications, such as 177Lu-labeled somatostatin analogs or ligands for prostate-specific membrane antigen [11 13].
An understanding of exosome biogenesis and composition will help to advance our understanding on the mechanisms by which MSCs are used in therapeutic applications.
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