Daphnia were bred and acclimatized in the laboratory under similar temperatures, light conditions and water quality as were used in the definitive test.
Fish obtained from Selcoth Fish Farm in Moffat, Scotland were used for the initial and repeat range finding tests, while fish from Brow Well Fisheries Ltd., Skipton, England were used in the definitive test.
As a local therapy, radiation can be used in the definitive, neoadjuvant, and adjuvant settings, often in conjunction with chemotherapy.
An objective of the pilot study is to estimate the SD for continuous outcomes to be used in the definitive trial as this will facilitate the sample size calculation for that study.
Due to these findings, we decided to use conventional randomisation in the definitive PACT study.
In addition to the satellite and observatory data selected for direct use in the modelling, minute mean definitive and quasi-definitive observatory data are used to estimate the Vector Magnetic Disturbance index (Thomson and Lesur 2007).
That map, first presented in 1865 and still in use today, remains the definitive documentation of the original coastlines of Manhattan Island, as well as of its streams and marshes — which by Viele's time were already being channelled and buried under piers, bulkheads, landfills, and foundations below the city's advancing grid.
To enable experimental modelling and evaluation of the interventions prior to their use in a definitive RCT – which also forms part of the IMP -, the interventions were developed in the context of an "intervention modelling experiment" (IME) [ 16].
We then stratify participants according to history of suicidality reported on standardised measures used in the initial assessments of eligibility, and use these measures as covariates in the definitive analysis.
Various approaches were tested, and the results obtained using maximum-likelihood methods implemented in PHYML were used for the definitive analysis (Guindon et al. 2005).
