Because the valuations of health states were intended to yield utilities that may be used in submissions to agencies like National Institute for Health and Clinical Excellence (NICE), most of whom require general population values, the inclusion criteria did not specify any particular clinical characteristics.
We consider that the integration of Laboratory Information Management systems (LIMS) and/or Experiment Management Systems (see in this supplement [ 25]) in lab-life operations of omics data, and its standardization (such as the use of ontology-derived nomenclatures) and use in submission to public data repositories will smooth the path towards efficient data discovery and sharing.
Unit costs were obtained from sources congruent with the Manual of Resource Items for use in Major Submissions to the Australian Pharmaceutical Benefits Advisory Committee involving Economic Analyses [ 6].
Particular emphasis is given to procedures such as non-human drug discrimination, self-administration, and physical dependence testing, and human dose-effect abuse liability studies that are commonly used in regulatory submissions to governmental agencies.
We used the Blat-like Fast Accurate Search Tool (BFAST, in submission) to map each sequence read back to its location in the reference genome.
Existing reports of utility values for metastatic non-small cell lung cancer (NSCLC) vary quite widely and are not all suitable for use in submissions in the UK.
Timor-Leste's representatives used their opening submissions to the court in The Hague to denounce the raid by Australian Security Intelligence Organisation (Asio), arguing national security interests were "not some magic wand" that allowed a country to wave away its obligations under international law.
The three main companies providing PBPK software used in clinical pharmacology regulatory submissions to date (GastroPlus, PK-Sim, and SimCYP) provided short summaries of their approach to system model qualification.
Although the STA process is different, and extensive scoping is carried out to provide a comprehensive decision problem, which guides the STA process, many of the same approaches continue to be used by manufacturers in their STA submissions to NICE.
It gained fame when matrix factorization methods were used in the winning submission to the Netflix prize [36].
