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Researchers use different routes of delivery of B. pseudomallei in experimental models to study the pathogenesis of the disease and the induction of host protection.
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This review focuses on contemporary developments of mucosal vaccination approaches using different routes of administration.
Finally, comparison of CD-treated Npc1−/− mice using different routes of administration suggested that SC injections were slightly more effective in ameliorating NPC1 disease progression than IP administration.
Using different routes of allergen application in BALB/c mice, ovalbumin epitopes were analyzed by induced antibodies revealing the tyrosine residue Y107 to be part of an ovalbumin epitope recognized exclusively after oral sensitization [39].
Systemic melioidosis can be generated in C57BL/6 mice by using different routes of infection, if a high dose is used.
Numerous studies using different routes of exposure and dose ranges have demonstrated an accelerated autoimmune response in MRL+/+ mice.
The clinical development of rIL-2 over the past 20 years has involved investigation of its clinical effects in several regimens using different routes of administration.
Over the intervening years, several formulations of experimental vaccines have been tested using different routes of immunisation and delivery vehicles to enhance immune responses - (Table 1).
The effect of PL on SW480 tumor growth in nude mice was also evaluated using different routes of administration and various doses (25-100 μg per mouse) for 14 d from the day of tumor inoculation.
Therefore, strategies to improve the immune response to vaccination have included using higher vaccine doses or increasing the number of doses, using different routes of administration, accelerating the dosing schedule, and using adjuvants such as antigen delivery systems and various immunostimulators [ 10].
Subsequently, they characterized the initial phases of zebrafish infection by using different routes of bacteria inoculation at early developmental stages; in most of the zebrafish embryos (which only have innate immunity) both local and systemic injections caused abundant brain infection, with formation of bacterial clusters that were identified as early granulomas.
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