I think Square-Enix, unlike Nintendo, has the right idea here: while it seems like Nintendo President Iwata thinks that smartphone gaming will sully Nintendo's history, Square-Enix is using different platforms to reignite existing fanbases and test out some interesting new IPs.
Our study strongly recommends biomarker assay optimization (especially those measured using different platforms) to reduce inter-study variability.
Such methodologies have significant hurdles to overcome: first, multiple studies are likely to use different platforms, different sample dissection, handling and preparation, and, especially, different definition of the non-diseased counterpart, resulting in different physical samples being hybridized against different platforms [1], [2], [3].
Another limitation is related to the fact that different studies use different platforms with the different sets of genes.
Because microarray datasets use different platforms and the data are presented in different formats, the microarray data were adjusted to similar scale and distribution patterns before class prediction based on four guidelines (for detail, see Additional file 2).
You will also have to use the same software as they do, and as they all use different platforms, this can involve licensing costs".
We used KEGG API to produce color-coded pathways shown in Figure 2. As different microRNA expression profiling studies use different platforms and different processing methods, there is the lack of agreement among these studies.
The large variability brought in by microarray datasets using different platforms is expected to affect the sensitivity and specificity of summary statistics constructed in various ways across studies.
New RCTs should be conducted in the near future to assess the feasibility of using different platforms for different clinical indications and to test for any potential increases in live birth rates resulting from more comprehensive aneuploidy screening before embryo transfer.
