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On the basis of our data, we propose that combining γ-secretase inhibition with Bcl-2/Bcl-xL targeting, might allow us to use concentrations of GSI under the side-effect limit in breast cancer therapy.
The underlying uptake processes did not saturate with cisplatin concentrations up to 400 μM in both WT and LRRC8A−/− cells (Fig EV3), allowing us to use concentrations exceeding therapeutic levels to increase the sensitivity of the assay.
These oils have use concentrations in the products of up to 100%[11]100%[11]
Most prebiotic simulations don't generate large amounts of fatty acids (Allen and Ponnamperuma 1967), with the exception of some hydrothermal vent simulations, which may use concentrations of reactants which are unreasonably high for these environments (McCollom et al. 1999).
Given de minimis or very small risks from exposures in areas of use, concentrations of CPY reported from semi- and remote locations present even lesser risks to birds or mammals.
Here, we use concentrations of iodate (the oxidized iodine species) in shallow-marine limestones and dolostones to generate the first comprehensive record of Proterozoic near-surface marine redox conditions.
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Many students cannot concentrate on studies so we use concentration exercises.
"You've got to use concentration".
"If an animal is trying to use concentration, it might be very misleading," she said.
Many important biochemical reactions, such as energy generation, use concentration gradients across membranes.
In vitro experiments with various cell types have routinely used concentrations of 10 to 100 µM.
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