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Our antibody fulfils two important prerequisites for use as targeting molecule to cancer cells; it is internalized (Online resource, Fig. 6), and, importantly, it does not stain normal human tissues except for weak staining of one of four normal breast samples.
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For example, antibodies are often used as targeting agents [9].
Theoretically, both linear and cyclic RGD peptides can be used as targeting biomolecules.
Mannosylated lipid core peptides (MLCPs) were used as targeting ligands for the liposome-encapsulated parasite antigens.
This small, drug-like ligand can be used as targeting device for drug delivery to hepatocytes.
Sugars have been also widely used as targeting moieties.
In this system, aptamers were used as targeting moieties.
For example, monoclonal antibodies are frequently used as targeting agents coupled to reporting agents.
Antibodies, antibody fragments and peptides have also been used as targeting moieties for drug delivery systems.
On Russian-language forums and chat groups, the investigators found detailed instructions on how to send disruptive messages, and which Estonian Web sites to use as targets.
Determine 3 markers on the driving range to use as targets.
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