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Compared to previous studies [8, 12 17], we do not start with the location and the time of an already known event, but we use an unsupervised approach that spatio-temporally identifies unusual calling behavior.
Some programs, such as StratomeX, use an unsupervised approach to explore the relationship between clinical parameters and patient stratifications based on molecular profiling [ 24].
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The designed segmentation method can be extended to images for which it is required to segment a region of interest using an unsupervised approach.
In [19], the authors used an unsupervised approach to adaptively identify the confidence of features in different circumstances.
Recent microarray analyses used an unsupervised approach to identify different molecular subtypes in medulloblastoma [30].
Using an unsupervised approach to classify data from TCGA, Verhaak et al. described 4 GBM transcriptomal subtypes, termed Proneural, Neural, Mesenchymal and Classical [36].
In 2/11 studies using an unsupervised approach, participants were willing to pay between (>US$20 to ≥US$50) [ 45, 46].
We next used an unsupervised approach to identify significant associations between genome-wide TF-binding data and gene expression.
This work used an unsupervised approach to predict the links based on several network toplogy features in co-authorship networks.
Using an unsupervised approach, we have identified five clinically relevant subtypes of breast tumors [ 4, 8], which have been further validated in independent data sets [ 3, 9- 14].
Privacy was more frequently reported as a benefit of HIVST in studies using an unsupervised approach (n = 5/6) [ 15, 30, 38, 45, 46] compared to those using a supervised approach (n = 2/6) [ 35, 37].
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