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The aim of this study, therefore, was to use an established model of active cartilage resorption to compare the temporal expression of metalloproteinases and their inhibitors and correlate this with pro-collagenase activation and aggrecan and collagen release.
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In the present study, we used an established model of developmental programming via maternal nutrient manipulation [29], [62].
In the present study, we used an established model of developmental programming via maternal global nutrient manipulation [5].
We used an established model of metabolic programming consisting on the restriction of protein to the dam during gestation and lactation as previously described [14].
To model the complications of diabetes, we used an established model of type 1 diabetic complications.
We used an established model of experimental pneumococcal meningitis in infant rats [ 13].
For the experimental glaucoma studies, we used an established model of ocular hypertension.
We used an established model (Soballe et al. 1992) in which the implants are weight bearing and surrounded by a circumferential gap of 0.75 mm.
In order to do this they used an established model of human DC differentiation from peripheral blood monocytes (Mo), based on addition of recombinant cytokines.
We used an established model of in ovo teratogen administration in which the teratogen is directly injected into the center of the yolk via a hole at the egg's blunt end.
Therefore, we used an established model of CA IX-transfected MDCK cells that show CA IX-mediated extracellular acidification when treated by hypoxia and accumulate FITC-CAI in hypoxia but not in normoxia.
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