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During the third treatment week until the end of week 23 of the trial the patient is allowed to use a total dose of 1.000 mg Diclofenac (max. dose 150 mg/day) or a total dose of 175 mg Rofecoxib (max. dose 25 mg/day).
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Single carbon atoms in graphene are typically observed with a S/N ratio of 2 at 80 kV using a total dose of ~20,000 e/Å2 [30].
In view of the impressive results obtained by Nigro and colleagues in 45 patients using a total dose of radiation of 30 Gy, we designed an institutional protocol taking into account the needs of this patient group and evaluated the toxicity and outcome using a total dose of 30 Gy of radiation delivered using an involved field approach with reduced dose concurrent 5-FU.
52 The total oral dose and dose regimens for paracetamol varied across trials, with 10 trials using a total dose of 3900-4000 mg/dandand three trials using 3000 mg/day (table 1).
These results have led to CRT (using a total dose of radiation of at least 50 Gy combined with 5-FU and MMC) being established as the primary treatment of anal cancer.
In a similar study, Nakayama et al. [46] used proton therapy to treat 55 medically inoperable patients with stage I NSCLC using a total dose of 66 GyE in 10 fractions for peripherally located tumors and 72.6 GyE in 22 fractions for centrally located tumors.
In a subsequent trial at the same institution that compared 3D-CRT and IMRT using a total dose of 81 Gy, the rate of rectal toxicity of IMRT was significantly lower than that of 3D-CRT (2% vs 14%) (Zelefsky et al, 2001).
Nihei et al. [45] applied proton therapy to treat 36 patients with stage I NSCLC using a total dose of 70 94 Cobalt gray equivalents (CGE) delivered in 20 fractions and found similarly high rates of local control (92.6%) and OS (81%) at 2 years.
Initially, a regimen was used with a total dose of 20 mg/kg LAMB, divided over 6 doses on alternate day.
TQ has good efficacy in preventing relapses up to six months by clearing vivax hypnozoites when used at a total dose of 300 mg or more (moderate quality evidence).
The multispecies combination of Tan and colleagues [ 1] was composed mainly of Bifidobacterium longum as well as Lactobacillus bulgaricus and Streptococcus thermophilus and was used at a total dose of 109 CFU per day.
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