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While there is not yet consensus on the preferred primary outcome measure in optic neuritis trials, Phase 2 proof-of-concept trials will likely use a structural marker such as RNFL or GCL + IPL thickness, whereas Phase 3 trials will need to demonstrate clinically relevant benefit on vision as well as structural preservation.
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(D – F ) Lef1 and Ccnd1 (CycD1) antibody stains in S-shaped body nephrons; Pax2 is used as a structural marker against all nuclei within the nephron, Jag1 is used to detect the medial segment, Wt1 is used to detect the developing podocytes in the proximal segment.
In this context, using the Lewy body as a structural marker for the progression of the disease may not be appropriate.
In the context of crush injury we used immunofluorescence to evaluate for the presence of p63 protein, a member of the p53 family of transcription factors, used as structural marker for epidermis (Stewart et al., 2009).
These muscle bundles are separated by an unstained central nerve cord, revealed by counter-staining using the structural marker YL1/2 (anti-tyrosylated-α-tubulin antibody), known to stain nerve cells with high intensity in Pleurobrachia pileus[ 40].
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