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The study will use a parallel design with the control group receiving the intervention after serving as control.
Standard CRTs typically use a parallel design where clusters are randomized to either a control or an experimental intervention for the entire study.
For the primary outcome of EMS call rate, we will collect at least 1 year of data before the intervention starts and also use a parallel design (for pairwise analysis) to examine the possible effect of seasonality.
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The difference in patient-reported outcomes between study arms can often be difficult to ascertain in randomized controlled trials (RCTs) using a parallel design because of wide interindividual variations in baseline characteristics and how patients interpret the outcome measures.
Four studies used a parallel design; the remaining one used a cross-over design.
Six trials used crossover designs (86%), and one used a parallel design (14%).
Participants were randomly allocated to one of 5 diets by using a parallel design.
All ten studies used a parallel design for the ibandronate and placebo or zoledronate arms.
This is particularly important for studies conducted using a parallel design, since this experimental design has a lower power than the cross-over design for relative bioavailability [ 14].
24 Using a parallel design, each eligible child was randomized to an intervention group or a control group with a 1 1 allocation ratio.
The trial was a multi-centred randomised controlled pilot trial using a parallel design with participants allocated to intervention or control on a 1 1 allocation ratio.
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