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Dr. Beutler of Scripps said that it was reasonable to use a high dose in the initial trial to prove the drug worked.
GFP is not the best fluorescent protein for IVIS system; so, we needed to use a high dose of bacteria.
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Is it more dangerous to use a higher dose, is there a titration schedule?
We therefore decided not to use a higher dose of pamidronate.
Also the study did use a higher dose of oxybutynin ER, up to 20 mg, while the darifenacin group only had 1 dose increase.
We would have preferred to use a higher dose of vitamin E, but this was not possible without an unacceptable increase in capsule size.
It has been found that programs that challenge balance and use a higher dose of exercises have greater relative effects on falls prevention [ 24].
For hydralazine, we found that we could achieve a full rescue of aortic root growth using a dose that was only ∼5 fold greater than that used in humans, and hence there seemed no need to use a higher dose.
Although the inoculation with p17/p24 protein alone was not immunogenic in mice, we may find if we use a higher dose with homologous boosts or adjuvant, that a Gag-specific immune response is induced.
In future studies it may be appropriate to use a higher dose of N-acetylcysteine and to compare N-acetylcysteine with placebo in patients with mild exacerbations who do not require treatment with corticosteroids.
To maintain the patient's blood pressure, we used a high dose of inotropic agents.
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