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We did not use a compartment model.
The calculations use a compartment model of glucose kinetics (25) describing the effect of rapid-acting insulin and the carbohydrate content of meals on glucose levels.
One cannot use a compartment model to predict the pharmacokinetics under varying physiological conditions, such as changes in portal, muscle or fat blood flow, or variations in plasma protein binding or body fat content.
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We model the cardiovascular system using a compartment model.
Analogous predicted TACs generated using a compartment model with a linear unimolecular binding component (i.e., not dependent on antigen concentration) were also generated.
When simulating a large bioreactor using a compartment model approach for hydrodynamics, our coupled model could predict that, under certain conditions, acetate is simultaneously produced and consumed in different areas of the reactor.
We used a compartment model with seasonality, waning of immunity and a Holling type II function, to model simultaneous contacts between a susceptible person and infectious ones.
To illustrate this hypothesis we used a compartment model to study the spread of the influenza virus in a completely immunological naïve population, from invasion to one year later.
The calculations used a compartment model of glucose kinetics [ 32], describing the effect of insulin on sensor glucose excursions.
The use of a compartment model may give a clinical sense to specific trajectory classifications and hence be useful for diagnostic, prognostic, or therapeutic purposes.
All these parameters cannot be used directly in a compartment model, and their transformation to compartment model PK parameters is essential.
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