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This choice strongly contributed to facilitate JORT's usage, achieving very high download rates: in 2012, 34,734 full-text articles were downloaded; last year the count rose up to 83,669, and preliminary 2014 data confirm this trend.
Therefore, these physiochemical characteristics of the MTX-PEG-CPT NRs were favorable for reducing the inert material usage, achieving the good physiological stability, and acquiring the suitable passive tumor-targeting effect via the enhanced penetration and retention (EPR) effect, which simultaneously make drug delivery/cancer therapy combined with cancer imaging possible.
However, a sensitivity analysis indicated that even if a 'usual dose' for zolendronic acid of 5 mg per year were used in calculations this would not account for the decline in total bisphosphonate usage (achieving 1.4 'usual daily doses'/1000 population/year by 2012; total bisphosphonate 'use' 11, rather than 10).
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The importance of both performance and usage on achieving impacts has long been recognized within the household energy sector.
As a stand-alone duplicate marking tool, it performs significantly better than PICARD or SAMBAMBA in terms of both speed and memory usage, while achieving nearly identical results.
Notably, in order to generate flexible tools for general usage in achieving fine control of gene expression, it would be useful to be able to combine elements of these different systems.
> -wrap-foot> Hydra-Multi ' s low memory usage is achieved primarily through the use of a memory assisted, k-way merge sorting algorithm and its speed is achieved largely through parallelization of both the discordant extraction and assembly phases (Supplementary Fig. S1).
Finally, optimum energy usage is achieved by the design of energy management strategy.
The coding region of PbYOP1 was optimized for yeast codon usage to achieve detectable expression.
There is now interest in increasing fuel ethanol usage to achieve nationwide levels of E20 or greater.
This performance improvement of overall resource usage is achieved at the cost of interoperator fairness, as illustrated in Figure 10.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com