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MST is approved under the trade name masivet in Europe and Kinavet in the USA at a dose of 12.5 mg kg−1 per day [10].
Following injection of either anti-E-selectin or anti-DNP (control) antibodies labelled with Dylight 750 nm NIR fluorophore (Thermo Fisher Scientific Inc., Rockford, IL, USA) at a dose of 5 μg i.v., paw swelling was induced by intraplantar injection of murine TNF-α into the right paw (RP) in C57/BL6 mice (marked by arrows) (n = 4 to 6).
Contrast-enhanced T1-weighted (CE-T1W) SE images after i.v. administration of 0.3 M Gd-diethylene triamine pentaacetic acid (DTPA) (from Magnevist®, Bayer, Whippany NJ, USA), at a dose of 0.3 mmol/kg b.w., were acquired using TR = 300 ms, TE = 10 ms and Av = 3.
On day 29, two injection of bromodeoxyuridine (BrdU; 5-bromo-2-deoxyuridine, Sigma, St . Louis MO, USA) at a dose of 50 mg/kg of was administered (i.p).
An agent was injected (0.5 µl) into one eye and PBS Gibco Laboratoriess, Grand Island, NY, USA) into the other (at P3 or P12) after mice were anesthetized with intraperitoneal injections of tribromoethanol (Sigma-Aldrich Corp., St . Louis MO, USA) at a dose of 250 mg/kg.
Mice were anaesthetized with an intraperitoneal injection of 1% pentobarbital (Gbico, USA) at a dose of 45 mg/kg.
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The title compounds were screened for their in vitro anticancer activity at National Cancer Institute (NCI), USA; at a single dose (10 μM) in NCI 60 cell line panel and results showed significant to good anticancer activity.
Doxycycline hyclate (Periostat®; CollaGenex Pharmaceuticals, Newtown, PA, USA), at a subantimicrobial dose, is the only MMP inhibitor approved by the US Food and Drug Administration as an adjunct therapy in adult periodontitis [ 120].
Cells destined for X-ray radiation at doses of 0 (control) 2, 5 or 10 Gy were exposed using the X-RAD 320 X-ray irradiation system (Precision X-ray, Inc., North Branford, CT, USA) at a higher dose rate of 0.98 ± 0.05 Gy/min.
As a constipation relief, linaclotide might be useful for patients with constipation due to aetiologies other than IBS; linaclotide has been studied in patients with chronic idiopathic constipation and is approved for this indication in the USA (at a lower dose of 145 μg), but not in Europe.
MB (Urolene Blue®, Star Pharmaceuticals, USA) was given at a dose of 10 mg per kilogram of body weight twice daily over three days.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com