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Bout had calculated that the FARC's "uptake" of arms could reach a hundred tons.
In a statement, shadow defence secretary Jim Murphy said there was no evidence the Falkland Islanders wished to change their nationality and added: "Something more important than the Empire's legacy was and is at stake: the universal right to self-determination and our belief that diplomatic dispute should be resolved by democracy rather than the uptake of arms".
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There is supportive data demonstrating higher patient uptake of allocated arm if randomisation occurred at baseline from a colorectal trial [ 16] and a lung cancer trial [ 17].
Noncompliance describes failure to comply with allocation in the intervention arm, and contamination describes uptake of the intervention in the control arm.
The extent of any overdiagnosis in trials of breast screening may be affected by the 'intensity' of screening (one or two views, modalities employed, screening frequency and recall policy), and by the uptake of screening in the intervention arm.
When rates of uptake of other drugs differ between treatment arms in long-term trials, the true benefit or harm of the treatment may be underestimated.
Adjustment for pre-intervention screening performance was quantitatively more important in the parallel testing group; nevertheless, uptake of screening in the two intervention arms was not significantly different from each other at 10 weeks' gestation (P=0.119).
Using two-sided Chi-Square tests for assessing three pair-wise differences between the different study arms and applying Bonferroni's correction (i.e., alpha = 0.0166 for each comparison), we sought to collect 97 patients in each arm to achieve 80% power to detect a 22% difference between arms given a baseline uptake of 60%.
However, it is unlikely that this was a major factor, as the uptake of cervical screening in the control arm of the study was only 4.5%.
The information sessions were part of a multifaceted implementation strategy designed to maximise uptake of the system across the three study arms (described later).
This is particularly the case when the uptake of such therapies differs between the treatment arms, potentially resulting in an underestimation of the direct benefit of the target treatment.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com