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As discussed, this hepatic and intestinal activity uptake is most probably the result of a slightly delayed overall clearance due to the enhanced lipophilicity of the tracer compared to [68Ga]pentixafor.
Their uptake is most likely initiated by binding to receptors at the membrane and triggering signalling processes required for uptake.
Under the condition of an intracellular reduced state determined by BME + BHA, cystine uptake is most likely a compensatory mechanism to maintain the adequate redox potential in these cells.
The liver and spleen uptake is most likely attributed to the host reticuloendothelial system.
Thus, the uptake is most likely related to the transient increase in oxygenation in the tumor tissue.
The general assumption is that MIBG activity on an I-MIBG scan, that is not explained by physiological uptake, is most likely a neuroblastoma tumour.
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42 FDG uptake was most accurate to predict long-term survival after neoadjuvant therapy.
While the inflamed muscles showed diffused, patchy or marginal signal abnormalities on MRI, FDG uptake was most prominent inside the muscles.
The decrease in DAT uptake was most pronounced in PSP patients during the first year, and the decrease slope was similar between the first and third year followup (the difference in DAT uptake ratios between baseline and the third year may not have reached significance due to the large variance at baseline and a small number of PSP patients at the last followup).
In rats, comparison of tracer accumulation in cryolesions characterised by the absence of inflammatory cells and radiation injury demonstrated that slight FET uptake was most likely due to a disruption of the blood-brain barrier and not additional trapping by macrophages.
Although a focal uptake pattern is most suggestive of CS, several studies have reported that fasting F-FDG uptake is inhomogeneous throughout the left ventricle in healthy subjects [ 61] and in oncologic patients [ 62], with regional maximal uptake in the infero-lateral and basal myocardium, probably because of local differences in substrate use [ 62].
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