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Hemodynamics, oxygen delivery index, and oxygen uptake index were monitored with catheters in the radial and pulmonary arteries (thermodilution).
Increases in interleukin-6, leukocyte count, and oxygen uptake index, all of which developed after CPB, were significantly less in the milrinone group than in the control group.
The experimental data represented in vivo log PS (permeability-surface area product) from in situ perfusion, brain uptake index, and intravenous administration studies.
The plant N uptake index (PNUI) based on NDVI of 807 nm combined with 736 nm was selected as the optimal vegetation index, and a linear model was developed with R2 of 0.870 and RMSE of 1.546 g N m−2 for calibration, and R2 of 0.834, RMSE of 1.316 g N m−2, slope of 0.934, and intercept of 0.001 for validation.
In clinical routine, a tracer uptake index is easily available and thus widely used, namely, the standardized uptake value (SUV) [2, 3].
The ratios of Cb/Cp (brain/plasma concentration ratios), an important indicator to evaluate the brain uptake index [10], [25], were used to further evaluate BBB penetration of honokiol.
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The PET uptake indices were further divided into values either less than or equal to the median value (Table 2) or values greater than the median value and associated with the expression of biomarkers.
Metabolically active tumour volumes as shown using MET uptake indexes of ≥1.3 and ≥1.5 and the volumes of Gd-DTPA enhancement showed a positive correlation (r = 0.76, p = 0.003, for an index of ≥1.3, and r = 0.74, p = 0.005, for an index of ≥1.5).
Metabolically active tumour volumes as shown using MET uptake indexes of ≥1.3 and ≥1.5 and the volumes of Gd-DTPA enhancement showed a positive correlation (r = 0.76, p = 0.003, for an index of ≥1.3, and r = 0.74, p = 0.005, for an index of ≥1.5; Spearman correlation; see Fig. 3).
When the tracer uptake indices were treated as continuous variables no correlation could be detected between the PET data and any of the endogenous biomarkers, although the expression of p53 showed a trend toward a correlation with [F]FDG SUV (rs =0.470, p =0.078), as shown in Table 4.> -wrap-foot>> -wrap-foot>> -wrap-foot> astandardized uptake value.
To calculate the volumes in cubic centimetres, a threshold-based volume-of-interest (VOI) analysis of the metabolically active tumour volume (MET uptake indexes of ≥1.3 and ≥1.5) and of the area of Gd-DTPA enhancement was performed after coregistration of all images.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com