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The improvement of oral bioavailability by particle size reduction is via increased dissolution rate rather than direct uptake; however, the approach of nanoparticle delivery might further improve efficacy and practicability of inhaled delivery and/or to overcome efflux transporter barriers in chemotherapy or CNS delivery.
Pik3cg-deficiency in MEFs also displayed an inhibitory effect on dextran uptake; however, the inhibitory effect observed in the mutant MEFs was significantly less than that of LY294002-treated cells (Figure 1A, P = 1.2×10−7, LY294002-treated Pik3cg+/+ vs. Pik3cg−/−).
The distribution pattern of FAT/CD36 was comparable to the pattern found for NPC1L1, but the highest protein expressions were found more distally than would be expected based upon the hypothesis of their role in proximal cholesterol uptake, however the patterns found in this study for NPC1L1 and FAT/CD36 were comparable.
An additional explanation could be a desensitization of TRPV1 during capsaicin treatment leading to a reduced SKM4-45-1 SKM4-45-1 SKM4-45-1e genuptakeechowevermustheurther be evaluated.
The post treatment FDG-PET/CT study showed complete resolution of FDG uptake; however, the CT study showed a relatively smaller but persistent hypodense lesion suggesting necrotic changes rather than residual tumour.
In this study, asiaticoside suppressed proliferation, decreased MIBI uptake and diminished the growth rate of in vivo 7,12 dimethyl benzanthracene (DMBA -induced mammary tumours in rats anDMBA -inducedF-7 cell uptake; however, the mammarysms for tumoursrocess remains unknown.
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The stomach wall was the organ with the highest uptake; however, this uptake was not homogeneous, distinguishing two different areas.
Uptake however, of the 'catch-up' campaign in England for 17-18 year old girls is below the 80% NHS target.
The efficiency of uptake, however, depended on the type of plasma lipid and the tumour.
Use of the maximum pixel value in a tumor to characterize tumor uptake, however, does make the measurement independent of the observer.
Substitution of Phe, Tyr, or Asn moieties for the glutamate portion of the novel peptide resulted in abrogation of novel CPP uptake; however none of the substituted peptides inhibited uptake of the novel CPP when coincubated with cells.
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