Thereby, an astrocyte glutamate uptake deficiency triggers an increase of the (v_{1}) value, and we observe an increase in the oscillation frequencies in the neural time series.
Hence in this scenario, when (v_{1}) increases as a consequence of the astrocytic glutamate uptake deficiency, we expect to observe a decrease in the oscillation frequency in the neural activity.
Moreover, in Sect. 3 about the astrocyte GABA uptake deficiency, we proved that, for a fixed value of (v_{1}), (p_{{mathrm{SNIC}}}) is linear and increasing with (v_{2}).
Note that this value can be tuned to obtain (v_{1}^) small enough and (p_{{mathrm{SNIC}}}) large enough so that the frequency after regulation is equal or lower than the one before uptake deficiency.
Based on the interpretation of the aggregated yet biophysically significant parameters of our model we have reproduced in silico both glutamate and GABA uptake deficiency in astrocytes and illustrated by numerical simulations the different types of change in the neural activity resulting from such deficiency.
At any rate, it cannot be excluded that the impaired survival in CDM and virulence defect of the trkH mutant might not be totally attributable to its potassium uptake deficiency.
Lack of the acinetobactin outer membrane receptor is followed by siderophore utilization disruption resulting in iron uptake deficiency.
The functionality of the transporter fusions was tested by complementation of ammonium uptake deficiency in a yeast mutant lacking endogenous ammonium transporters (Marini et al., 1997).
Interestingly, a cardiac NE uptake deficiency, characterized by decreased clearance of NE in the heart, and decreased DHPG NE ratios, like that seen in POTS, has been described in individuals with depression (Barton et al., 2007).
DNA binding activity to these sites was markedly increased in tumoral tissue compared to normal tissue, suggesting that this alteration may cause reduced promoter activity of the Na+/I- symporter gene and determine I- uptake deficiency in human thyroid tumors.
