Sentence examples for upstream to it from inspiring English sources

Mutations within the motif from position 5 onward, including the single substitution of the central A (mut5), severely decreased transcription whereas mutations in the first four positions of the motif or in the sequence upstream to it had no significant effect (Fig. 7A).

To examine in more detail the sequence requirements for TISU to act as a transcriptional element and its relation to YY1, several successive blocks within the motif or upstream to it in the PSMD8 promoter were mutated (Fig. 7A, middle panel, mut2 and mut4 correspond to mut1 and mut2 in Fig. 5B).

Pathogenicity clusters were further extended if the initially defined cluster has PSEP-encoding genes downstream or upstream to it and two interruptions by nonsecreted protein-coding genes were allowed if the following gene was again a PSEP-encoding gene.

It's a sort of Herzogian thing about finding one flashbang moment of excruciating human high-drama, and then uncoiling it, following it upstream to see where it leads, unpicking the hearts of the people caught up in its wake.

Sure, Xi has rerouted all tributaries of power to run upstream to him, but isn't it in the service of rejuvenation?

Our S.U.V. eventually made it upstream to our hotel, giving a whole new meaning to the expression "we sailed into town".

According to Christensen's theory, a "disruptive" business has to either originate in a low-end market and move upstream to higher value markets, or it has to create a "new market foothold," meaning it creates a new market where none existed.

Nor has it moved upstream to enterprise products like high-end servers or storage.

This study further demonstrates that HY1 additively or synergistically functions with HY5, however it works upstream to MYC2 in JA signaling pathways.

Nevertheless, since RNA splicing is coupled with transcription and splicing of exons is largely sequential from upstream to downstream [ 48, 49], it could be expected that the adjacent exons are more likely to interact with each other than a distant pair.

Instead it's moving upstream to the aggregator space.