We derive optimal stopping rules for upstream and downstream stages' testing, together with the optimal time elapsed between beginning the upstream tests and beginning the downstream development.
Thus, to cancel the CLIF assay because another upstream test (for example, anti-dsDNA ELISA) delivered a negative test result might circumvent a correct diagnosis of SLE in some cases.
In the rpd3 mutant we could not discern any changes in histone H4 or H3 acetylation levels compared to wild-type over the entire FLO1 upstream region tested (Fig. 6B and C, rpd3).
We chose the PAX3-upstream site for testing because, according to the RRBS data, it was not only a MbMt-hypermethylated site but also one of the 17 sites in this region that was significantly hypomethylated (most sites at p < 10−6) in FSHD MbMt vs. analogous control MbMt (Fig. 2).
Though more detailed analyses of the nature of the links (synergistic or parallel) between these pathways and SMN are necessary, we provide strong evidence supporting a connection between BMP signaling and Smn at NMJ by testing additional upstream and downstream elements of this pathway.
Testing major upstream and signal transducing pathways, NO-induced cruciate ligament cell death seemed to be mediated on different levels.
VPT was tested upstream toward agricultural sector for sugar beet price, and downstream toward the retailing sector for retail price.
Therefore, the distinctions between the following sites were tested: upstream, where water is free from anthropogenic activities, such as industries, domestic sewage and agricultural contaminations, and downstream, where the effluent disposal of all industries and the municipal sewage are discharged.
We have used short-term acid exposure and leptin as experimental upstream activators to test involvement of the Akt pathway.
