Sentence examples for upstream stress from inspiring English sources

The complex interactions of Bcl-2 family protein members therefore can integrate highly diverse upstream stress signals into a response of mitochondrial outer membrane permeabilisation (MOMP).

Cardiac hypertrophy and CHD are mediated by transcription factor integration of upstream stress signals, and Mef2d-deficient mice have an attenuated hypertrophic response to cardiac stress [ 34].

The transducers link upstream stress signaling to the induction of mitochondrial outer membrane permeabilization (MOMP) by Bax and Bak, resulting in caspase activation and apoptosis.

Exposure of HeLa S3 cells to nsPEFs quickly induced phosphorylation of eIF2α, activation of its upstream stress-responsive kinases, PERK and GCN2, and translational suppression.

Such a comprehensive study requires assessment of RAGE and subsequent intracellular signal transduction involving NF-κB and its upstream stress-related kinases, including mitogen-activated protein kinases, p38, and c-jun N-terminal kinases (Dourazar et al. 2005).

Indeed, the impairment of autophagy, either by targeting ATG genes or the upstream ER stress process, leads to a significant upregulation of the innate immune response to HCV [ 54, 69, 95].

Although altered mitochondrial morphology has been implicated in many neurodegenerative diseases (Chen et al., 2007; Palmer et al., 2011), this loss of normal morphology did not appear to be the primary cause of cellular dysfunction in GD neurons, but rather a secondary effect of upstream cellular stress.

14 Large numbers of predicted TFBS are observed upstream of stress-upregulated genes.

On the other hand the results of inhibition of ATF3 by shRNA in Figure 6A suggest that JNK activation is upstream of ER stress.

In fact, we have shown that 4-oxo-4-HPR-induced ROS generation occurred earlier than the mitotic arrest, thus indicating that the antimitotic activity of the retinoid was not an event upstream the oxidative stress.

Interestingly, TUDCA appeared to reduce cleaved Caspase3 and CHOP induction, while not appearing to reduce JNK activation (Figure 3) suggesting that in this case JNK activation is upstream of ER stress.