Sentence examples for upstream stimulus from inspiring English sources

In fact, it is the entire spectrum of characteristics (e.g., metabolic and neuro-coordinative) of the upstream stimulus (resistance vs. endurance exercise; RE vs. E) that determines the downstream events necessary for training adaptations to occur.

These data strongly implicate intracellular H2O2 as the upstream stimulus that controlled both autophagy and apoptosis in this model.

One means to validate the effectiveness of the URA is to test its predictive capabilities using datasets derived from cells treated with a defined upstream stimulus.

Our results suggest that a therapeutic strategy to inhibit the upstream stimulus for PI-3Kinase through blockade of growth factor receptors may provide a workable alternative.

To examine whether IGF-1R is a possible upstream stimulus of the PI3K/Akt/mTOR pathway in BCSCs, we first tested the activation status of Akt/mTOR between BCSCs and non-BCSCs.

Additionally, it is possible that approaches such as using hemoperfusion through a column packed with the LPS-binding agent, polymyxin B [ 106, 107], can indirectly decrease circulating levels of HMGB1 by removing the upstream stimulus for secretion of the protein.

However, it remains unclear which upstream stimuli preferentially use the p53-p21 patoway triggerger senescence.

Numerous studies have demonstrated that AC proteins are regulated by upstream stimuli in various cell types [14].

Despite extensive research on upstream stimuli that activate AMPK, few studies have been conducted to investigate the downstream substrate(s) of AMPK-mediated glucose uptake.

In general GEFs stimulate the dissociation and exchange of bound GDP (guanosine diphosphate) for GTP (guanosine triphosphat) on Ras in response to upstream stimuli.

It is well established that such biological response of a gene by an upstream stimuli would depend upon integration of a number of pathways.