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Together our results indicate that ERK activation by a yet unknown factor is the most upstream step of regeneration initiation identified in planarians so far, leading to fst activation and subsequent inhibition of Activin signaling.
The step of producing copper sulfate could be avoided if copper sulfate solution from the upstream step of copper production is used.
It should be noted that because the task selection step is an upstream step in the tutorial process any bad decision regarding task selection would propagate to later, downstream tutoring stages.
This is the most upstream step of autophagosome formation.
These results indicate that LPS induces IκBα degradation by acting at an upstream step to NF-κB activation.
These results suggest that PMX464 works as either a non-reversible inhibitor of the IKK complex or inhibits activation of IKK complex at an upstream step.
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For the first stimulation, release kinetics mainly reflects the ultimate exocytosis step, but as the AP train progresses, release kinetics increasingly involves slower, more upstream steps, namely docking (slow release) and supply from the reserve pool (asynchronous release).
They usually operate on massive amount of data and require many upstream steps including object alignment, 3D-to-2D projections and normalization.
In a dataflow with pipeline processing, like the one considered, it is natural that the QoD of previous or upstream steps influence the executions of current and downstream steps in the pipeline, since the inputted data is derived from upstream, i.e., from the beginning of the processing.
However, this effect on the final secretion step may (in part) be explained by action of Rab3 in more upstream steps.
However, since it is unlikely that calcium remains bound to the immunoprecipitated MEKK2, we favor the possibility that the calcium interferes with upstream steps in the MEKK2-ERK5 activation.
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