Sentence examples for upstream responses from inspiring English sources

Such a framework should make it possible to characterize and illustrate the interconnectedness of key event pathways and the upstream responses that produce those events.

Rather than basing a risk assessment on predictions of a cellular response made from a TP model, an assessment could be based more directly on upstream responses that would otherwise serve as inputs to a TP model.

The analysis supports the hypothesise that initiation of cell death is a common final pathway resulting from a multitude of upstream responses to the insult and resultant cellular stress of cytotoxic chemotherapy or radiotherapy thereby accounting for gene expression overlap seen.

Dyclonine induces the Nrf2 [nuclear factor (erythroid-derived 2 -like 2 -likescription factor, which we show binds an upstream response element in the FXN locus.

One possible explanation for this temporal variation is that the expression of upstream response genes (including TFs) was gradually reduced during osmotic stress recovery, with the upstream cascade genes then activated during ionic stress.

Experiments in the past have shown IL-6 to be an intermediate for Reg2 and Reg1 gene induction in the pancreas, since the IL-6 upstream response element is conserved among these Reg genes [ 5, 22].

Id mRNA was constitutively expressed in rat osteoblastic osteosarcoma ROS17/2.8 cells and its level was transcriptionally suppressed by 1 α,25(OH)2D3 [ 50]. 1 α,25(OH)2D3 exerted its negative effect on Id1 gene transcription via the 57 bp upstream response sequence (−1146/−1090) [ 49].

Consequently, the change in an upstream response necessary to produce an adverse apical response may depend on the baseline response, and it could reasonably be the case that no single amount of perturbation of a biochemical or genomic response will be without risk for all members of a population.

The nature, magnitude, and pathways responsible for the initiation and persistence of inflammation vary between diseases, but upstream signaling responses may be activated ubiquitously.

TRAF3, STING, and TBK1 form a signaling complex that transmits upstream sensory responses to downstream effectors and then phosphorylates IRF3 to activate type I IFN production.

TRAF3 binds to TBK1 and forms a complex with TBK1, linking upstream signaling responses of RIG-I/Mda5-MAVS-STING to the TBK1-directed phosphorylation of IRF3 and IFNβ transcription (Fig. 6A) (Fitzgerald et al., 2003; Oganesyan et al., 2006).