indicates that IPA was not able to predict upstream regulation of that specific upstream regulator for the specific exposure condition.
Furthermore, upstream regulation of a given miRNA can involve multiple regulators at different steps of miRNA biogenesis.
Taking into account that miRNAs regulate gene expression, it becomes clear that the upstream regulation of their own levels is crucial for cellular homeostasis and behaviour.
Interestingly, ATFs with upstream regulation are common constituents of FFLs [5], with the ATF and the additional regulator as Y and X of this motif, respectively (Fig. 1.E), so we asked if this association could reveal any pattern.
Upstream regulation and effectors of NF-κB reprogramming barrier.
Andhra Pradesh's lack of success can be attributed to upstream regulation and arm's length contractual design.
TOR complexes function in feedback loops, implying that downstream effectors are also likely to be involved in upstream regulation.
This is an interesting discussion: subsidies for renewables versus carbon tax versus (my personal preference) upstream regulation of the fossil fuel industry to drive the development of carbon capture.
Hopper, N. A., Harwood, A. J., Bouzid, S., Véron, M. & Williams, J. G. Activation of the prespore and spore cell pathway of Dictyostelium differentiation by cAMP-dependent protein kinase and evidence for its upstream regulation by ammonia.
Joseph Aldy and William Pizer, in Chapter 4, focus on the relationship between upstream regulation and downstream employment by estimating the spillover effects on manufacturing from regulation-induced price increases in electricity.
Included among the many genes associated with risk of schizophrenia are the gene encoding the dopamine D2 receptor and those involved in the upstream regulation of dopaminergic synthesis, through glutamatergic and gamma-aminobutyric acidergic pathways.
