"upstream issues" is correct and commonly used in written English.
It refers to problems or challenges that arise earlier in a process or chain of events, often causing difficulties or complications downstream. Example: The company is experiencing financial difficulties due to upstream issues with suppliers not delivering their products on time.
In parallel with Ofcom's investigation into the so-called "upstream" issues raised by Virgin, the Competition Appeal Tribunal is considering a long-running legal row over the wholesale price charged for Sky Sports to its rivals that threatens to put Bleak House's Jarndyce v Jarndyce to shame.
Do you guys want to know anything else? [Devin says: Peter and I played this little fridge magnet game. Worked fine, so no upstream issues.].
Thus policy options may be developed to address health inequalities at various life stages [ 1], and to tackle upstream issues that underlie the social determinants of health [ 35].
As such, issues pertaining to vulnerability require careful and context-specific empirical and normative analyses that can extend to many of the upstream issues often considered outside of the realm of intervention research methodology (e.g., randomized controlled trials; pharmaceutical research).
With the exception of the two studies published by the Stanford group [ 12, 13], no other empirical data regarding students' actual experiences of obtaining personal genomic data in an educational setting is yet available, either regarding the downstream psychological and educational effects or the upstream issues around informed decision-making.
According to the authors, there are three key components for improved access: availability (addressing both "upstream" issues of product discovery and development and "downstream" challenges of national pharmaceutical supply systems), affordability (sustainable funding and low prices), and safe and effective medicine use (rational use, quality and safety) [ 35].
Bar coding of samples coupled to automation of steps prior to sequencing has the potential to handle most upstream process issues.
Debates focused largely on the efficiency of CAMR, identifying intellectual property protection and upstream implementation issues as impeding the participation of both the generic industry and developing country governments.
From migration to terrorism, disease pandemics to climate change – the more we can do to tackle these issues upstream and overseas, the better we can protect ourselves here at home.
For example, upstream uncertainty captures issues related to suppliers' poor delivery reliability (Holweg et al., 2011) or defective rates of incoming lots (Gray et al., 2011).
In particular, the focus on protecting intellectual property, complying with the TRIPS Agreement and the right of refusal clause effectively displaced the deliberation of other equally valid policy goals as well as upstream policy implementation issues.
