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This mechanism permits dynamic downstream responsiveness to constant upstream input, disentangling specific pathways from the full network.
Upstream, input was given by providing the Uniform Resource Identifier (URIs) for the UniProt identifiers of P-gp and BCRP in the form of a table.
GEFs thus link diverse upstream input signals to control the actin cytoskeleton.
In such decision points, the activities of the switch genes in the mono-stable regime go to zero if the upstream input signal vanishes.
Future work will be required to address how each upstream input to mTOR contributes to TFEB regulation.
However, following Met receptor activation, Brk acts primarily as an upstream input to ERK5 activation, mediating increased cell migration.
Similar(47)
It is composed of a core kinase cascade that is regulated by multiple upstream inputs (for review see refs. 15, 17).
As elements of signaling pathways, second messengers can serve to integrate information when multiple independent upstream inputs influence the rates of synthesis and degradation of the second messenger.
Upstream inputs currently regulated by the dam of guard.
Taken altogether, regulation of mammalian Hippo signaling is complex and likely incorporates multiple upstream inputs to determine intensity and duration of signal activation.
Daf-16 was known to receiving several upstream inputs to regulate their downstream effects, such as IIS pathway and the silent information regulator 2 (SIR2) [24].
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