Sentence examples for upstream hub from inspiring English sources
Researchers often choose a specific element to target (e.g., VEGFR2 tyrosine kinase inhibitor) using statistical analysis of gene expression, or the target's ability to affect cell fate (i.e., does the target act as an upstream hub?).
Researchers often choose a specific element to target (e.g., the VEGFR2 tyrosine kinase inhibitor) using statistical analysis of gene expression, or the target's ability to affect cell fate (i.e., does the target act as an upstream hub?).
Here we rely on recent genetic and cellular findings to construct a model proposing that traffic jams in the early endosome can act as an upstream pathogenic hub in AD.
While PHYTOCHROME-INTERACTING FACTOR4 (PIF4) has been identified as a major ambient temperature signaling hub, its upstream regulation seems complex and is poorly understood.
Notably, it has been shown that miR-494 may act as a convergent hub for upstream oncogenic transcriptional factors, such as H-Ras, c-Jun, c-Fos, and E2F family.
Hence, Box et al. [ 27] and this study confer complementary evidence for a central role of ELF3 as a major signaling hub acting upstream of PIF4 in the ambient temperature signaling network and add yet another layer to its complex regulation (Fig. 5).
It is also interesting to observe that the mean FFLness of the Y-elements being part of the significant FFLs (beyond MarA, i.e., FliA, NarL, ArcA and RpoE) is F = 0.34, while a much smaller averaged value was observed for the rest of hubs with upstream regulation and non-significant co-regulations, i.e., F = 0.07.
To gain further insight into functional hubs and their relevance to psoriasis, we built network modules consisting of sets of genes linked to hubs by upstream or downstream functional connections.
* USB 2.0 hub with one upstream and two downstream ports.
The river site near industrial hub and the upstream site had similar biological diversity.
TSC1/2-Rheb functions as a major hub to transduce upstream signals to mTOR.
