Sentence examples for upstream function from inspiring English sources
In Saccharomyces cerevisiae, changes in carbon source lead to gene induction by Adr1 and Cat8 that are known to require the upstream function of the Snf1 protein kinase, the central regulator of carbon metabolism, to exert their activating effect.
In agreement with previous data, MT-dAsb11 was unable to induce her4 gfp upon exposure of DAPT [11], showing the hierarchical upstream function of d-Asb11 in canonical Notch activation.
Our data suggest an upstream function of the miRNAs in coordinating tissue specification and energy mobilization to ensure proper growth and development of the grain.
Specifically, the AFD thermosensory neurons (i.e., the neuronal pair AFDR and AFDL) detect temperature through a nucleotide-gated channel TAX-2/TAX-4, which requires the upstream function of several guanylyl cyclases, one of which is GCY-8.
Here, we investigate the temporal responses of local fish beta diversity to hydrologic modification by the upstream functioning dams in five sites of the Mekong-3S system.
In addition, caspase-3 is an executioner caspase that has downstream functions in apoptosis, while caspase-2 is an initiator caspase with upstream functions in apoptosis.
The topological structure of such network of pathways reveals the signalling pathways as upstream functions would be causes of disease, and the disease-relevant pathways as downstream functions would link to those upstream pathways by crosstalk.
Modules at the top, performing essential upstream functions, span large evolutionary distances virtually unchanged, while lower level modules, involved in peripheral sub-networks, show a higher level of adaptation [ 12].
For Cnox-5 we suggest a more upstream regulatory function.
Coronary microangiopathy is associated with a reduction of upstream dilatatory function of epicardial coronary arteries [ 56].
These data thus uncover JNK signaling as a novel upstream regulator functioning in suppression of these critical epithelial determinant genes during EMT.
