Human error is not a cause, but a consequence, which is shaped and provoked by the upstream factors [8].
However, the extent to which spindle orientation controls division symmetry or cell fate, and the upstream factors regulating this process, are still elusive.
Recent researches have been successful in identifying the upstream factors of this pathway by screening EMS-mutated Arabidopsis with the CRT/DRE element or CBF/DREB promoter-driven reporter gene [25, 26, 191].
For example, in the health sciences, an expansion of the understanding of health risk has occurred to include the upstream factors behind health outcomes including socioeconomic inequalities and unfair power structures (CSDH 2008).
Upstream factors of the PI3K/AKT pathway are likely candidates.
It can also help target the upstream factors that have the most potential for influencing mortality.
However, little is known about the upstream factors and signaling mechanisms that regulate midkine gene expression.
We thus need to better understand upstream factors that shape drinking at college.
RTKs are important upstream factors in oncogenic signaling cascades and also targets for drug development.
However, the upstream factors and signaling mechanisms that regulate MDK expression have not been identified.
The SBM includes three domains of these upstream factors: predisposing, enabling, and medical need.
