Sentence examples for upstream factor is from inspiring English sources

This indicates that although mutations are absent, the RAS/RAF/MEK/ERK pathway is essential for UM growth and suggests that an upstream factor is involved in autonomous UM proliferation.

One such upstream factor is the Akt signaling pathway: its capacity to inhibit the activity of FOXO transcription factors was shown to regulate the expression of the genes encoding atrogin-1 and MuRF1 (Sandri et al., 2004; Stitt et al., 2004).

Studying feed forward loops as a group of network motifs (Reviewed in [ 36]) assumes that the contribution of the direct and indirect effects of the upstream factor are equal and similar for all genes.

Therefore, the screen output appeared to validate our unbiased approach, as both proximal and upstream factors were detected.

It could be that Indigenous disparities in receipt of DGA care (along with many other health outcomes) will persist until such fundamental upstream factors are addressed.

While these upstream factors are body-site specific, Wnt/β-catenin signaling is required universally by all mammary placodes - and indeed by all ectodermal appendages [ 36].

The possibility that the observed regulation of S100A4 expression by IFN- γ was a secondary event caused by IFN- γ-induced cell cycle arrest or apoptosis was excluded, and indications for reduced transcription caused by upstream factors were obtained.

These upstream factors are important barriers to health care utilization and vital components for public health approaches, especially when screening, vaccination and early treatment makes significant impacts on infectious diseases like HBV [ 1].

Upstream factors are those that exist at a community or national level and impact behaviors at a macro level, such as town planning that either encourages or discourages walking for transportation.

The upstream sound power factor is less than the downstream power factor, which is generally large, especially away from the cut-off frequency.

Hence, an upstream common splicing factor is expected to be present in hymenopterans, simultaneously controlling all three downstream target genes (fem/ tra, dsx and fru).