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Identification of upstream factor(s) regulating OsWRKY11 is required to elucidate OsWRKY11-mediated cross-talk between the abiotic and biotic stress response pathways.
Instead of different process in manufacture, the new error modeling approach regards each axis as a station in MAS, and calculates the deviations after each station which is considered as upstream factor to next station.
Although proposed [43], we could not identify a solution with Bub3 as the most upstream factor.
The networks I use here are simplified in that each gene is regulated by a single upstream factor, whereas real genes are often multiply regulated.
The observation that we could reprogram using only Oct4 but not Nanog alone, suggests that Oct4 is likely an upstream factor for cellular reprogramming.
Alternatively, depletion of IK2 mRNA in puf2 could be an indirect effect due to activation of an upstream factor that regulates IK2.
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Human error is not a cause, but a consequence, which is shaped and provoked by the upstream factors [8].
However, the extent to which spindle orientation controls division symmetry or cell fate, and the upstream factors regulating this process, are still elusive.
Recent researches have been successful in identifying the upstream factors of this pathway by screening EMS-mutated Arabidopsis with the CRT/DRE element or CBF/DREB promoter-driven reporter gene [25, 26, 191].
For example, in the health sciences, an expansion of the understanding of health risk has occurred to include the upstream factors behind health outcomes including socioeconomic inequalities and unfair power structures (CSDH 2008).
Upstream factors of the PI3K/AKT pathway are likely candidates.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com