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Duncan, R. et al. A sequence-specific, single-strand binding protein activates the far upstream element of c-myc and defines a new DNA-binding motif.
R-loop formation is hereby initiated on the target at an upstream element, called protospacer adjacent motif (PAM), from which the R-loop structure zips directionally toward the PAM-distal end of the target.
In analogy with electrical networks, downstream of the global search component there is a parallel of two alternative elements, i.e. two local search algorithms with different features in terms of search logic, whose purpose is to refine the search in the regions detected by the upstream element.
Extract a list with all elements in the network (name, type and upstream element and downstream element, if a pipe or connector) and separate them in edges and nodes.
UAF binds to upstream element located at upstream of the 35S pre-rRNA gene to activate the transcription of the 35S precursor RNA gene by recruiting CF and Pol I.
On the as well as on the strand, several sequences were identified related to retroviral regulatory elements like retroviral polyA signals or a lentiviral TATA upstream element.
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Davis-Smyth, T., Duncan, R. C., Zheng, T., Michelotti, G. & Levens, D. The far upstream element-binding proteins comprise an ancient family of single-strand DNA-binding transactivators.
Activated c-Abl can phosphorylate parkin at tyrosine 143 leading to inhibition of parkin's E3 ligase function and accumulation of its toxic substrates, such as PARIS (PARkin Interacting Substrate 15, aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 (andP2) and far upstream element-binding protein 1 (FBP1)9,15,16.
We found another antigen, far upstream element-binding protein 2 (FUBP = KHSRP), to be recognised by all five pools of sera from GCA patients in VSMC protein extracts.
Phosphoglycerate kinase 1 (PGK1), stress-induced phosphoprotein 1 and the far upstream element-binding proteins (FUSE-BP) 1 and 2 were identified as new antigens.
Previous studies identified that far upstream element-binding protein 1 (FBP1), a transcriptional regulator of c-Myc that is one of the most frequently aberrantly expressed oncogenes in various human cancers, including NPC, is an important biomarker for many cancers.
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