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Indeed, 17.1% (13/76) of the respondents who had used research tools reported that they had to abandon their projects due to research tool (or upstream discovery) patents.
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The NRC National Research Councill) provided a series of case studies on the use of patents, which covered a small number of important research tools (especially foundational upstream discoveries), and found that "restricted access" to upstream discoveries and tools had occurred [ 5].
Empirical investigations in the US have also confirmed the existence of access problems, especially for upstream discoveries.
Has your research been changed due to patented research tools or prior upstream discoveries? 1) Yes 2) No Q7.
Has your research been abandoned due to patented research tools or prior upstream discoveries? 1) Yes 2) No Q8.
What do you think is the main effect of patented research tools or prior upstream discoveries? 1) Fostering information sharing among researchers 2) Improving research productivity 3) Increasing research cost 4) Restricting access to information 5) Stifling effect on subsequent innovation 6) Other ________________________________ Q9.
A recent report on open science released by the UK Royal Society further illustrates the promise of 'massively parallel collaboration' for upstream scientific discovery, study design and research question formulation: Live and open debate played out via wikis and blogs have changed the dynamic of academic discussion - sometimes in extreme ways.
They provide evidence of transcriptionally active regions in an organism and are an excellent resource for upstream work including gene discovery, functional genomics and marker discovery [ 35, 36].
They could potentially support the FDA, and drug discovery further upstream".
The use of synovial MSCs and discovery of upstream transcriptional regulators that help maintain the AC phenotype have opened new avenues to improve the outcome of AC regeneration.
Thus, the discovery of upstream pathways in different cells types that contribute to multiple pathological cardiometabolic processes in T2D may lead to a unique class of T2D therapies that have increased efficacy and safety than those that are currently available.
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