Sentence examples for upstream alterations from inspiring English sources

In summary, sensory sensitivity was unaltered in any of the mouse models, and thus, deficits in delay eyeblink conditioning were not accompanied by upstream alterations in sensory sensitivity or downstream deficits in blink capability.

To determine if the alteration in LC3-II levels upon LRRK2 inhibition is due to upstream alterations in the mTOR pathway the phosphorylation of p70S6K, S6 and 4EBP1 (downstream translational inhibition targets of mTORC1) was examined in the presence of LRRK2-in1.

Any major upstream alteration to a river system, or increase in use of shared groundwater, should be negotiated, not imposed.

Based on these results, we put forward the falsifiable hypothesis that co-targeting a specific upstream alteration and a general downstream point of vulnerability is a good strategy to prevent or overcome resistance to targeted drugs.

In conclusion, we propose an anti-cancer strategy of co-targeting a specific upstream alteration and a general downstream point of vulnerability to prevent or overcome resistance to targeted drugs.

Co-targeting a specific genomic upstream alteration (here, a BRAFV600E mutant) and a general downstream point of vulnerability (here, c-Myc) may be an effective strategy to overcome drug resistance, as it has the potential dual advantage of specificity and generality.

We assume that upstream retinal alterations have led to a secondary peak time prolongation.

As a result, these top ranked significantly differentially expressed genes or modules represent the cancer phenotype changes, whereas upstream genomic alterations aid in locating the changing source.

Pertinent to human disease, the deregulation of Hippo pathway components promotes cancer development through multiple mechanisms including inactivating mutations in upstream regulators, epigenetic alterations, loss of heterozygosity, alterations in copy number, and deregulation of associated molecular pathways.

Morais et al propose that defects in the mitochondrial respiratory chain lie upstream of these alterations.

An alternate explanation for the increased expression of ribosomal and other genes associated with cell growth reflects alterations upstream of the mammalian Target of Rapamycin (mTOR) pathway.