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Given the connectivity between the hillslope and the watershed, changes in land cover upstream affect river levels in the downstream basin, and can increase flood risk in environments under increasing pressure of agriculture (Zhang and Schilling, 2006) and urban development (Nirupama and Simonovic, 2007).
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If less water comes downstream because of the dams, the lake will not flood as usual and the fish will not be able to migrate upstream, affecting the food supplies of millions of people.
Jeff Tittel, the director of the New Jersey chapter of the Sierra Club, said that deepening would push the river's salt line farther upstream, affecting drinking water, and that blasting could fracture the riverbed and allow PCB's, heavy metals and other toxins in the sediment to leech into the underground aquifer.
Since the upstream region affect the downstream subproblem, the subproblems were solved in order, from the upstream (A) to the downstream (B).
The results show that the roughness blocks both on the hill surface and on the upstream ground affect the speed-up ratio over the hill.
The mechanism by which the upstream sequences affect the specificity of interaction remains unclear.
It is known that both the sequence of the binding domain and the upstream sequences affect PDZ domain interactions.
Moreover, dynamic monitoring of an individual cell is difficult since the secretions of the cells upstream may affect others.
The regulator effects algorithm connects upstream regulators, dataset molecules and downstream functions or diseases affected in the dataset to generate a hypothesis that can explain how the upstream regulators affect the downstream target molecule expression and the impact of the molecular expression on functions and diseases.
Applying such sensors has revealed that cultured mammalian cells effectively defend their redox poise: neither imposition of unfolded protein load (so-called ER stress), nor manipulations that compromise the upstream oxidases, affect the steady-state disposition of ER localized redox sensors [ 8, 9].
The over- or underexpression of splicing factors and their upstreams may affect cis-elements availability or spliceosome assembly to influence splicing machinery.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com