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In people with severe depression, it appears to be upregulated, or expressed at too high a concentration.
While he notes that other growth factors and body chemicals are "upregulated" by exercise, he believes BDNF holds the most promise.
If we drink a lot of alcohol an enzyme that metabolises it becomes more active – "upregulated" in the jargon.
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CEO of Professional Science Editing for Scientists @ prosciediting.com