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A total number of 43 genes that were found to be upregulated in this study as a consequence of induction of cardiomyocyte differentiation were combined in a gene set, named 'VAN_DARTEL_HEARTDIFF_24H'VAN_DARTEL_HEARTDIFF_24H
In total 49 of the 122 genes were reported as significantly upregulated in this study and further 58 genes were reported slightly but not significantly upregulated.
The gpi, gltX, and spr1880 genes downstream of guaA were not upregulated in this study.
In addition, PRDX1 was found to be upregulated in this study.
Furthermore genes associated with macrophages and T cells were discovered to be upregulated in this study [ 19].
Although IL-13 was also upregulated in this study using the bleomycin model, its expression was at a relatively late stage and occurred after collagen deposition.
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Ribosomal protein 40S and 60S and RNA binding family protein are also highly upregulated in this transcriptome study.
The score incorporates a weight for each experiment that is inversely proportionally to the number of genes upregulated in the study.
Among the genes that had only little association with DS before we found FBN1 which was predominantly upregulated in the studies under analysis (in 80% of the expression studies; upregulated in 4 out of 5 human studies and in 3 out of 5 DS mouse models (from the ones with a detection P-value <0.1; Fig. 1A).
In fact, none of the translationally upregulated mRNAs in this study showed increased abundance in our previous analysis of the UPR transcriptome under the identical conditions [ 6].
Along a similar line, another highly upregulated gene in this study is nephroblastoma overexpressed (NOV) also referred to as CCN3 [ 95] (fold change = 7.33).
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