Indeed, transgenic mouse hearts expressing constitutively active STAT3 show upregulated expression of the free radical scavenger, metallothionein [ 35].
Both hMECs and hESCs upregulated expression of cardiac markers upon differentiation, but they exclusively expressed genes for myosin light chain (Myl2, Myl7) and myosin heavy chain (Myh6), respectively.
The upregulated expression of APX can be seen as an antioxidative defense in plants.
Dexamethasone upregulated expression of nephrin and tubulin-α, and downregulated vascular endothelial growth factor.
Specifically, fibre networks enabled cell infiltration and upregulated expression of actomyosin proteins in contrast to flat hydrogels.
As shown in in vitro differentiation experiments, the treated mesenchymal stem cells (MSCs) adapted to a round-shape hepatic cell characteristic morphology with upregulated expression of albumin [7].
Most importantly, the artificial cartilages molecularly resembled native cartilage as evidenced by high accumulation of cartilage-specific ECM components and upregulated expression of cartilage-critical genes.
The result indicates that OxLDL that induces hPBMCs showed an upregulated expression of TLR2, TLR4, NF-κB, pro-inflammatory cytokines and VCAM-1.
The upregulated expression of p-ERK, aceH3K9 and BDNF in the VLO might be the underlying mechanism of histone acetylation enhancing the morphine-induced behavioral sensitization.
MLCP-liposomes, but not unmannosylated liposomes, were taken-up efficiently by APCs which then significantly upregulated expression of MHC-ll and costimulatory molecules, CD80 and CD86.
Emulsigen upregulated expression of chemokines CCL2 and CCL5, proinflammatory cytokines IL-6 and TNFα, as well as TLR9, and several IFN response genes.
