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Unlike cystatin C, β2-microglobulin decreased significantly with gestational age so that the upper reference limit was 7.19-0.052 × gestational age in weeks.
The determination of the upper reference limit (URL) for thyroid peroxidase autoantibodies (TPOAbs) is a contentious issue, because of the difficulty in defining the reference population.
This study aimed to determine the 99th percentile upper reference limit (URL) concentration of cardiac troponin I (cTnI) with a high-sensitivity assay in a Korean population.
Upper reference limit.
The upper reference limit (URL) announced by the manufacturer was 0.046 µg/L.
PMI was defined according to Universal definition (troponin I or CK-MB ≥ 3 times the 99th percentile of the upper reference limit).
Patients affected by HT were selected according to the following criteria: ultrasound hypoechogenicity and if the thyroperoxidase antibodies (TPOAbs) levels were higher than the upper reference limit.
The estimation of the upper reference limit (URL) for TPOAbs is a controversial issue, because of an uncertainty as to the criteria for correctly defining the reference population.
eURL = 99.0th ‰; Δ = ∣mURL − eURL∣/mURL × 100 CI confidence intervals, CV coefficient of variation, eURL experimental upper reference limit, IMM Immulite 2000 XPi, KRY Kryptor Compact Plus, LIA Liaison XL, MAG Maglumi 2000 Plus, mURL manufacturer's upper reference limit, PHA Phadia 250, SD standard deviation.
The ratios of 8 out of 9 trisomy 18 samples were above the upper reference limit.
The ratios in all of the trisomy 18 placenta were above the upper reference limit (Figure S3).
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