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This was performed 10 000 times and lower and upper confidence boundaries were obtained from this distribution of the bootstrapped means.
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Hofmann et al. [3] observed high variability in Urtica leaf pollen density values with a 95% upper confidence boundary of 2270 n/cm2 and maximum leaf density values of up to 13,802 n/closelose to the pollen source (0.2 m).
In the primary analysis, none of the placebo-corrected changes from baseline at any time point for either granisetron preparation exceeded 1.9 milliseconds (msec), and the maximum observed 90% upper confidence boundary was 6.88 msec, well below the threshold of 10 msec for regulatory concern.
The cumulative z curve crosses neither the traditional boundary nor the trial sequential monitoring boundary but does cross the futility boundary, suggesting firm evidence for a lack of even an average 7.5% relative risk increase (upper confidence limit 11%) of myocardial infarction with angiotensin receptor blockers (see fig B1 in appendix 3 on bmj.com).
Upper confidence limit.
They obtained a non-parametric upper confidence bound for R.
LCL: lower confidence limit UCL: upper confidence limit.
max is + 2 for the 95percentt upper confidence limit.
aOR, odds ratio; LCL, lower confidence limit; UCL, upper confidence limit.
OR: Odds Ratio; LCL: 95% Lower Confidence Limit; UCL: 95%Upper Confidence Limit; Ref: Reference Category.
Visual inspection of the location of Alu-derived exons on the GC2/GC3 plot shows that they have relatively higher GC2, typical of non-coding sequence, and 41.79% fall outside the 95% confidence interval, all of which fall above the upper confidence interval boundary (See Additional file 2).
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